IL18 and IL18R1 polymorphisms, lung HRCT and fibrosis: a longitudinal study in coal miners
نویسندگان
چکیده
Rachel Nadif, Margaret Mintz, Jacqui Marzec, Anne Jedlicka, Francine Kauffmann, Steven R. Kleeberger, 1 INSERM U780, Villejuif, France 2 Université Paris Sud, Faculté de médecine, IFR69, Villejuif, France 3 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD USA 4 Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC USA
منابع مشابه
IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners.
It has been suggested that interleukin (IL)-18 plays a role in the development of inflammatory and fibrosing lung diseases. Associations of polymorphisms in the genes coding for IL-18 (IL18 /G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL18R1 /C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999. Coal-dust exposure was ass...
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OBJECTIVES Current diagnostic standards of pneumoconiosis, which is the most serious occupational disease in China, are based on film-screen radiography (FSR). However, parenchymal structure overlap limits the sensitivity of FSR in the clinic. High-resolution computerized tomography (HRCT) has the advantage of identifying nodular pulmonary parenchymal changes. In this study, we aimed to compare...
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BACKGROUND Genetic association studies demonstrated a role for cytokine proteins and cytokine or cytokine receptor gene polymorphisms in smallpox vaccine-induced adaptive immunity. METHODS We examined the association of genetic polymorphisms with cellular (interferon [IFN] γ enzyme-linked immunospot assay [ELISPOT]) immune response to smallpox vaccine in 1076 immunized individuals. RESULTS ...
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